rs6989943

This is a intron variant variant in the RGS22 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

basal cell carcinoma

Seviiri M et al. “A multi-phenotype analysis reveals 19 susceptibility loci for basal cell carcinoma and 15 for squamous cell carcinoma.” Nature Communications 13(1):7650 (2022)

Allele A

OR —

p 1.0e-137

N 307,684

Large GWAS

European

About RGS22

Enables G-protein alpha-subunit binding activity. Predicted to be involved in negative regulation of signal transduction. Located in actin cytoskeleton; cytosol; and fibrillar center. [provided by Alliance of Genome Resources, Jul 2025]

View all RGS22 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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