rs702485
This is a 3 prime utr variant variant in the DAGLB gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
high density lipoprotein cholesterol measurement
Spracklen CN et al. “Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.” Human Molecular Genetics 26(9):1770-1784 (2017)
Allele A
OR 0.02
p 1.0e-14
N 222,097
Large GWAS
multi-ancestry
Hoffmann TJ et al. “A large electronic-health-record-based genome-wide study of serum lipids.” Nature Genetics 50(3):401-413 (2018)
Allele A
OR —
β 0.021
p 4.0e-9
N 94,674
Large GWAS
multi-ancestry
Willer CJ et al. “Discovery and refinement of loci associated with lipid levels.” Nature Genetics 45(11):1274-1283 (2013)
Allele A
OR —
β 0.024
p 6.0e-12
N 94,595
Large GWAS
European
waist-hip ratio, high density lipoprotein cholesterol measurement
Huang LO et al. “Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities.” Nature Metabolism 3(2):228-243 (2021)
Allele G
OR —
p 7.0e-14
N 413,810
Large GWAS
multi-ancestry
About DAGLB
Enables lipase activity. Involved in arachidonate metabolic process. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all DAGLB variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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