rs7072776

This variant is located in the MLLT10 gene.

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

smoking initiation

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)
Allele G
OR 0.01
p 4.0e-42
N 2,669,029
Large GWAS
European
Liu M et al. “Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use.” Nature Genetics 51(2):237-244 (2019)
Allele G
OR 0.01
p 1.0e-9
N 931,815
Large GWAS
European

Uterine leiomyoma, breast carcinoma

Wu X et al. “Investigating the shared genetic architecture of uterine leiomyoma and breast cancer: A genome-wide cross-trait analysis.” American Journal of Human Genetics 109(7):1272-1285 (2022)
Allele A
OR —
p 2.0e-23
N 550,152
Large GWAS
European

breast carcinoma

Michailidou K et al. “Association analysis identifies 65 new breast cancer risk loci.” Nature 551(7678):92-94 (2017)
Allele A
OR 1.05
p 2.0e-19
N 139,274
Large GWAS
multi-ancestry
Shu X et al. “Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants.” Nature Communications 11(1):1217 (2020)
Allele A
OR 1.06
p 2.0e-19
N 277,932
Large GWAS
multi-ancestry
Michailidou K et al. “Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.” Nature Genetics 47(4):373-80 (2015)
Allele A
OR 1.07
p 1.0e-14
N 33,832
Large GWAS
European
Michailidou K et al. “Large-scale genotyping identifies 41 new loci associated with breast cancer risk.” Nature Genetics 45(4):353-61, 361e1-2 (2013)
Allele A
OR 1.07
p 4.0e-14
N 22,627
Large GWAS
European

sodium measurement

Pazoki R et al. “GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits.” Nature Communications 10(1):3653 (2019)
Allele A
OR 0.01
p 7.0e-14
N 446,237
Large GWAS
multi-ancestry

About MLLT10

This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

View all MLLT10 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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