rs708727

This is a synonymous variant in the SLC41A1 gene — it does not change the protein's amino acid sequence.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body mass index

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.03

p 3.0e-12

N 607,391

Major Consortium StudyLarge GWAS

multi-ancestry

monocyte count

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)

Allele A

OR 0.02

p 1.0e-10

N 170,721

Large GWAS

European

Tinnitus

Clifford RE et al. “Genetic architecture distinguishes tinnitus from hearing loss.” Nature Communications 15(1):614 (2024)

Allele A

OR 5.46

p 5.0e-8

N 481,874

Large GWAS

European

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ClinVar annotation

Benign★★★☆

2 submitters2 publications

View on ClinVar →

About SLC41A1

Enables magnesium:sodium antiporter activity. Involved in cellular response to magnesium ion; intracellular magnesium ion homeostasis; and magnesium ion transmembrane transport. Located in basolateral plasma membrane. Part of protein-containing complex. Implicated in nephronophthisis. [provided by Alliance of Genome Resources, Jul 2025]