rs7089814

This variant is located in the ZNF365 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

breast size

Eriksson N et al. “Genetic variants associated with breast size also influence breast cancer risk.” Bmc Medical Genetics 13:53 (2012)

Allele C

OR 0.10

p 3.0e-9

N 16,175

Large GWAS

European

About ZNF365

This gene encodes a zinc finger protein that may play a role in the repair of DNA damage and maintenance of genome stability. The N-terminal C2H2 zinc finger motif is required to form a protein complex with PARP1 and MRE11, which are known to be involved in the restart of stalled DNA replication forks. A mutation in this gene may be associated with breast cancer susceptibility. [provided by RefSeq, Mar 2020]

View all ZNF365 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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