ZNF365

zinc finger protein 365

Summary

This gene encodes a zinc finger protein that may play a role in the repair of DNA damage and maintenance of genome stability. The N-terminal C2H2 zinc finger motif is required to form a protein complex with PARP1 and MRE11, which are known to be involved in the restart of stalled DNA replication forks. A mutation in this gene may be associated with breast cancer susceptibility. [provided by RefSeq, Mar 2020]

Known Variants43 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs371518407	10:64,135,965	G/C	—	uncertain significance
rs144485380	10:64,136,020	G/A	—	uncertain significance
rs191288886	10:64,136,038	C/T	—	uncertain significance
rs2492049507	10:64,136,044	G/A	—	uncertain significance
rs373853921	10:64,136,152	C/A	—	uncertain significance
rs760459662	10:64,136,239	C/T	—	uncertain significance
rs776601568	10:64,136,430	C/T	—	uncertain significance
rs530339038	10:64,136,452	G/A	—	uncertain significance
rs139813334	10:64,136,519	G/T	—	uncertain significance
rs779148649	10:64,136,598	C/T	—	uncertain significance
rs139132215	10:64,136,656	G/A	—	uncertain significance
rs1873686	10:64,136,751	G/C	—	benign
rs1873687	10:64,136,875	C/T	—	benign
rs3852424	10:64,148,125	C/A	—	benign
rs531423000	10:64,148,163	T/C	missense variant	—
rs2132417903	10:64,148,217	C/T	—	uncertain significance
rs745708419	10:64,148,235	T/C	—	uncertain significance
rs116297631	10:64,148,315	C/G	—	uncertain significance
rs2893897	10:64,148,369	A/G	—	benign
rs2306970	10:64,158,746	G/A	—	benign
rs3758490	10:64,159,333	T/G	—	benign
rs7089814	10:64,187,564	C/G	—	—
rs11818163	10:64,219,296	C/A	—	benign
rs10995170	10:64,223,383	T/C	intron variant	—
rs11819488	10:64,239,709	A/G	—	benign
rs78864773	10:64,239,746	A/G	—	benign
rs12774545	10:64,382,662	A/G	—	benign
rs145971452	10:64,382,959	A/G	—	uncertain significance
rs145414368	10:64,414,648	G/T	—	likely benign
rs10822043	10:64,415,031	G/A	—	benign
rs1394285433	10:64,415,161	C/T	—	likely benign
rs748962642	10:64,415,276	A/G	—	uncertain significance
rs146014775	10:64,415,401	G/C	—	benign
rs7094595	10:64,415,413	T/A	—	benign
rs117615414	10:64,415,976	A/G	—	benign
rs76895268	10:64,416,220	C/T	—	benign
rs12776269	10:64,416,290	G/A	—	benign
rs111695652	10:64,425,798	C/T	—	benign
rs74156086	10:64,425,913	C/A	—	likely benign
rs73289245	10:64,425,922	C/A	—	benign
rs4746516	10:64,426,056	T/G	—	benign
rs74156089	10:64,429,997	A/G	—	benign
rs114275831	10:64,430,232	C/A	—	benign

Gene information from NCBI Gene. Variant classifications from ClinVar.