rs71519209

This is a upstream gene variant variant in the FCGR2C gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

platelet volume

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.02

p 7.0e-17

N 394,642

Large GWAS

European

low affinity immunoglobulin gamma Fc region receptor II-b measurement

Kalnapenkis A et al. “Genetic determinants of plasma protein levels in the Estonian population.” Scientific Reports 14(1):7694 (2024)

Allele T

OR 0.41

p 2.0e-11

N 497

Small GWAS

European

About FCGR2C

This gene encodes one of three members of a family of low-affinity immunoglobulin gamma Fc receptors found on the surface of many immune response cells. The encoded protein is a transmembrane glycoprotein and may be involved in phagocytosis and clearing of immune complexes. An allelic polymorphism in this gene results in both coding and non-coding variants. [provided by RefSeq, Apr 2012]

View all FCGR2C variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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