rs7174250
This is a intron variant variant in the ABHD17C gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Agents acting on the renin-angiotensin system use measurement
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele T
OR 0.04
p 9.0e-11
N 416,256
Large GWAS
multi-ancestry
hypertension
Guindo-Martínez M et al. “The impact of non-additive genetic associations on age-related complex diseases.” Nature Communications 12(1):2436 (2021)
Allele T
OR 1.08
p 4.0e-8
N 56,637
Large GWAS
European
aging
Rosoff DB et al. “Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging.” Nature Aging 3(8):1020-1035 (2023)
Allele C
OR 0.01
p 5.0e-8
N 1,559,001
Large GWAS
European
About ABHD17C
Enables palmitoyl-(protein) hydrolase activity. Involved in protein depalmitoylation. Predicted to be located in dendritic spine; postsynaptic density membrane; and recycling endosome membrane. Predicted to be active in endosome membrane; glutamatergic synapse; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
View all ABHD17C variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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