rs717454

This is a downstream gene variant variant in the REV1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

uterine fibroid, age at menopause

Xiao C et al. “Genetic contribution of reproductive traits to risk of uterine leiomyomata: a large-scale, genome-wide, cross-trait analysis.” American Journal of Obstetrics and Gynecology 230(4):438.e1-438.e15 (2024)

Allele T

OR —

p 2.0e-13

N 504,302

Large GWAS

European

About REV1

This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq, Mar 2016]

View all REV1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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