REV1
REV1 DNA directed polymerase
Summary
This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq, Mar 2016]
Known Variants71 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2544987854 | 2:100,017,796 | C/G | — | uncertain significance |
| rs758902128 | 2:100,019,151 | T/C | — | likely benign |
| rs777891716 | 2:100,019,155 | A/C | — | uncertain significance |
| rs143727824 | 2:100,019,157 | T/G | — | uncertain significance |
| rs763046340 | 2:100,019,221 | T/C | — | likely benign |
| rs368073401 | 2:100,019,245 | T/C | — | uncertain significance |
| rs41280589 | 2:100,019,256 | A/T | — | benign |
| rs143534521 | 2:100,019,361 | C/G | — | uncertain significance |
| rs573088136 | 2:100,019,495 | C/T | — | likely benign |
| rs1162292889 | 2:100,019,548 | T/C | — | uncertain significance |
| rs373008850 | 2:100,020,180 | G/T | — | uncertain significance |
| rs2545021128 | 2:100,020,209 | T/C | — | uncertain significance |
| rs187858098 | 2:100,020,257 | C/G | — | uncertain significance |
| rs145941027 | 2:100,020,919 | T/C | — | benign |
| rs200483066 | 2:100,020,978 | G/T | — | uncertain significance |
| rs2545034278 | 2:100,021,122 | C/T | — | uncertain significance |
| rs1224725170 | 2:100,022,442 | T/C | — | uncertain significance |
| rs528811652 | 2:100,022,463 | G/T | — | uncertain significance |
| rs142684849 | 2:100,022,476 | C/G | — | uncertain significance |
| rs149229135 | 2:100,022,487 | G/A | — | uncertain significance |
| rs767169436 | 2:100,022,520 | C/G | — | uncertain significance |
| rs780806643 | 2:100,022,539 | A/G | — | likely benign |
| rs550221075 | 2:100,022,562 | C/T | — | uncertain significance |
| rs717454 | 2:100,022,772 | T/G | downstream gene variant | — |
| rs1435617327 | 2:100,022,830 | T/G | — | uncertain significance |
| rs2545051182 | 2:100,022,834 | A/T | — | uncertain significance |
| rs763262673 | 2:100,022,844 | G/A | — | uncertain significance |
| rs760779228 | 2:100,022,871 | G/C | — | uncertain significance |
| rs1047186043 | 2:100,024,533 | G/T | — | uncertain significance |
| rs2545068430 | 2:100,024,574 | C/T | — | uncertain significance |
| rs2545091331 | 2:100,027,209 | G/C | — | uncertain significance |
| rs1322536048 | 2:100,027,247 | C/T | — | uncertain significance |
| rs764635157 | 2:100,029,233 | G/A | — | uncertain significance |
| rs138472841 | 2:100,029,278 | C/T | — | uncertain significance |
| rs2545111032 | 2:100,029,318 | A/G | — | uncertain significance |
| rs1677368381 | 2:100,029,332 | T/C | — | uncertain significance |
| rs765459821 | 2:100,029,393 | A/G | — | uncertain significance |
| rs755436677 | 2:100,029,396 | C/T | — | uncertain significance |
| rs7597141 | 2:100,034,331 | A/G | intron variant | — |
| rs775907424 | 2:100,038,042 | T/C | — | uncertain significance |
| rs11887109 | 2:100,045,184 | A/G | intron variant | — |
| rs528473417 | 2:100,046,372 | A/C | — | uncertain significance |
| rs746740911 | 2:100,050,889 | C/A | — | uncertain significance |
| rs2545318943 | 2:100,052,307 | G/A | — | uncertain significance |
| rs1042664313 | 2:100,052,364 | C/T | — | uncertain significance |
| rs1681079211 | 2:100,055,159 | T/C | — | uncertain significance |
| rs1032393262 | 2:100,055,171 | T/G | — | uncertain significance |
| rs200143519 | 2:100,055,261 | C/G | — | uncertain significance |
| rs140633437 | 2:100,055,273 | C/T | — | uncertain significance |
| rs138092700 | 2:100,055,347 | T/C | — | uncertain significance |
| rs761370730 | 2:100,055,407 | C/T | — | uncertain significance |
| rs2545349730 | 2:100,055,428 | G/C | — | uncertain significance |
| rs755435304 | 2:100,055,431 | C/A | — | uncertain significance |
| rs765517314 | 2:100,055,438 | G/C | — | uncertain significance |
| rs781428956 | 2:100,055,455 | C/G | — | uncertain significance |
| rs147808086 | 2:100,055,496 | C/T | — | likely benign |
| rs3087386 | 2:100,055,506 | A/G | missense variant | — |
| rs373000879 | 2:100,055,543 | T/C | — | likely benign |
| rs376222421 | 2:100,055,603 | A/G | — | uncertain significance |
| rs970768290 | 2:100,055,619 | T/G | — | uncertain significance |
| rs2545354256 | 2:100,055,718 | C/T | — | uncertain significance |
| rs374255141 | 2:100,055,725 | T/C | — | uncertain significance |
| rs373976399 | 2:100,055,732 | T/G | — | uncertain significance |
| rs759209603 | 2:100,055,762 | C/T | — | likely benign |
| rs3792142 | 2:100,057,208 | C/A | intron variant | — |
| rs963304534 | 2:100,058,804 | T/C | — | uncertain significance |
| rs1681638222 | 2:100,058,900 | G/C | — | uncertain significance |
| rs57977991 | 2:100,060,441 | C/T | intron variant | — |
| rs1451246 | 2:100,064,283 | C/T | — | — |
| rs146592953 | 2:100,079,038 | C/T | — | uncertain significance |
| rs6761390 | 2:100,106,797 | C/T | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.