rs7177008

This case-control study examined whether LINGO1 gene variants (rs9652490, rs11856808, rs7177008) associated with essential tremor also confer risk for Parkinson's disease in an Austrian population of 349 PD patients and 345 controls. No significant associations were found between any LINGO1 SNP genotypes or alleles and PD (rs9652490 p=0.61), nor in the subgroup of tremor-dominant PD patients (n=34, p=0.76). The findings argue against a major role of LINGO1 variants in PD susceptibility despite the documented clinical overlap between the two disorders.

This case-control study investigated whether LINGO1 gene polymorphisms associated with essential tremor also confer risk for Parkinson's disease (PD). Three SNPs (rs9652490, rs11856808, rs7177008) were genotyped in 349 PD patients and 345 controls from Austria. No significant associations were found between any LINGO1 variants and PD risk overall (p=0.61 for rs9652490) or in tremor-dominant PD patients, arguing against a major role of LINGO1 variants in PD susceptibility.