LINGO1
leucine rich repeat and Ig domain containing 1
Summary
Predicted to enable epidermal growth factor receptor binding activity. Predicted to act upstream of or within negative regulation of oligodendrocyte differentiation; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and neuron development. Predicted to be located in plasma membrane. Predicted to be active in several cellular components, including extracellular space; glutamatergic synapse; and presynapse. Implicated in autosomal recessive intellectual developmental disorder 64 and glaucoma. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants85 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1001008204 | 15:77,906,400 | T/A | — | uncertain significance |
| rs113716376 | 15:77,906,419 | G/A | — | benign |
| rs780397720 | 15:77,906,422 | G/A | — | likely benign |
| rs367728067 | 15:77,906,424 | C/T | — | uncertain significance |
| rs1344902763 | 15:77,906,433 | T/C | — | uncertain significance |
| rs2549263766 | 15:77,906,454 | G/C | — | uncertain significance |
| rs2549263945 | 15:77,906,474 | T/G | — | uncertain significance |
| rs2549264155 | 15:77,906,538 | C/T | — | uncertain significance |
| rs200917454 | 15:77,906,581 | G/A | — | likely benign |
| rs369774840 | 15:77,906,614 | G/A | — | likely benign |
| rs11853548 | 15:77,906,674 | G/A | — | benign |
| rs61737307 | 15:77,906,692 | G/A | — | likely benign |
| rs759222486 | 15:77,906,739 | C/T | — | uncertain significance |
| rs142861123 | 15:77,906,746 | G/A | — | likely benign |
| rs1200453719 | 15:77,906,753 | G/A | — | uncertain significance |
| rs199659139 | 15:77,906,791 | G/A | — | likely benign |
| rs769417669 | 15:77,906,806 | C/T | — | likely benign |
| rs868551107 | 15:77,906,843 | T/C | — | uncertain significance |
| rs377260390 | 15:77,906,864 | C/T | — | uncertain significance |
| rs2549265747 | 15:77,906,867 | G/T | — | uncertain significance |
| rs2073622195 | 15:77,906,884 | G/A | — | likely benign |
| rs370042281 | 15:77,906,890 | C/T | — | likely benign |
| rs568947342 | 15:77,906,891 | G/A | — | uncertain significance |
| rs945687158 | 15:77,906,898 | C/T | — | uncertain significance |
| rs768903780 | 15:77,906,927 | G/A | — | uncertain significance |
| rs766890349 | 15:77,906,969 | C/T | — | uncertain significance |
| rs755355674 | 15:77,906,975 | C/T | — | uncertain significance |
| rs147726308 | 15:77,907,055 | C/T | — | likely benign |
| rs765631433 | 15:77,907,065 | G/A | — | uncertain significance |
| rs199628078 | 15:77,907,078 | G/A | — | uncertain significance |
| rs61737308 | 15:77,907,139 | C/T | — | benign |
| rs3743481 | 15:77,907,145 | G/A | synonymous variant | benign |
| rs753336987 | 15:77,907,179 | G/A | — | uncertain significance |
| rs375759643 | 15:77,907,241 | G/A | — | likely benign |
| rs776160711 | 15:77,907,252 | C/T | — | uncertain significance |
| rs187712243 | 15:77,907,304 | C/T | — | likely benign |
| rs776220853 | 15:77,907,310 | C/A | — | likely benign |
| rs763006902 | 15:77,907,354 | T/C | — | uncertain significance |
| rs757077698 | 15:77,907,380 | C/T | — | pathogenic |
| rs767873726 | 15:77,907,381 | G/A | — | conflicting classifications of pathogenicity |
| rs750612085 | 15:77,907,386 | T/C | — | pathogenic |
| rs1209288929 | 15:77,907,417 | C/T | — | uncertain significance |
| rs193100227 | 15:77,907,428 | T/C | — | uncertain significance |
| rs141129663 | 15:77,907,451 | C/T | — | likely benign |
| rs2549269240 | 15:77,907,510 | A/T | — | uncertain significance |
| rs2271396 | 15:77,907,535 | C/G | — | benign |
| rs376324371 | 15:77,907,581 | C/T | — | uncertain significance |
| rs2549270467 | 15:77,907,763 | C/T | — | uncertain significance |
| rs767833518 | 15:77,907,765 | T/G | — | uncertain significance |
| rs2271397 | 15:77,907,775 | T/C | synonymous variant | benign |
| rs2271398 | 15:77,907,784 | G/A | synonymous variant | benign |
| rs757926173 | 15:77,907,788 | T/A | — | uncertain significance |
| rs866352031 | 15:77,907,797 | C/T | — | uncertain significance |
| rs764093658 | 15:77,907,881 | G/A | — | uncertain significance |
| rs150289554 | 15:77,907,954 | C/T | — | uncertain significance |
| rs370164787 | 15:77,907,975 | C/T | — | likely benign |
| rs2142484967 | 15:77,908,005 | G/A | — | uncertain significance |
| rs2142485096 | 15:77,908,029 | G/A | — | uncertain significance |
| rs751163599 | 15:77,908,091 | C/T | — | uncertain significance |
| rs377521757 | 15:77,908,102 | G/A | — | likely benign |
| rs749922029 | 15:77,908,103 | G/A | — | uncertain significance |
| rs758540036 | 15:77,908,129 | C/T | — | likely benign |
| rs747055318 | 15:77,908,130 | G/A | — | uncertain significance |
| rs371015975 | 15:77,908,135 | C/T | — | likely benign |
| rs904431701 | 15:77,908,160 | A/G | — | uncertain significance |
| rs772748227 | 15:77,908,179 | G/C | — | uncertain significance |
| rs1346131570 | 15:77,908,194 | G/A | — | uncertain significance |
| rs753710707 | 15:77,908,215 | C/T | — | uncertain significance |
| rs76669376 | 15:77,908,251 | G/A | — | benign |
| rs749567236 | 15:77,917,794 | G/T | — | — |
| rs574047775 | 15:77,924,643 | C/T | — | likely benign |
| rs765942091 | 15:77,924,661 | G/T | — | likely benign |
| rs8030859 | 15:77,955,516 | C/T | intron variant | — |
| rs9652490 | 15:77,963,887 | A/G | downstream gene variant | — |
| rs7177008 | 15:77,965,200 | C/G | downstream gene variant | — |
| rs11856808 | 15:77,972,770 | C/T | intron variant | — |
| rs59511331 | 15:77,991,899 | T/G | — | — |
| rs55858810 | 15:78,004,230 | G/T | intron variant | — |
| rs11856579 | 15:78,012,688 | G/A | intron variant | — |
| rs34543037 | 15:78,016,551 | T/C | intron variant | — |
| rs4886904 | 15:78,027,178 | C/G | — | — |
| rs12903563 | 15:78,033,735 | T/C | intron variant | — |
| rs62007784 | 15:78,034,703 | C/G | — | — |
| rs11629621 | 15:78,080,737 | C/G | coding sequence variant | — |
| rs3935182 | 15:78,094,807 | G/C | intron variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.