rs9652490

A pilot association study examining single nucleotide variants rs6280 in DRD3 and rs9652490 in LINGO1 genes and their association with levodopa-induced dyskinesias (drug dyskinesia) in Parkinson's disease patients from Yakutia, Russia. The study of 47 PD patients (7 with dyskinesias, 40 without) found no statistically significant association between either SNV and drug dyskinesia development (p > 0.05), though longer levodopa therapy duration and higher equivalent daily levodopa doses were significantly associated with dyskinesia risk.

Case-control study of 200 essential tremor (ET) patients and 250 healthy Spanish controls found no significant associations between GABRR1/GABRR2/GABRR3 polymorphisms (rs12200969, rs1186902, rs282129, rs832032) and ET risk. The GABRR polymorphisms were also unrelated to age of onset, tremor localization, or response to ethanol treatment.

Case-control study of 542 Taiwanese subjects (273 ET patients, 269 controls) demonstrating association of the SLC1A2 rs3794087 A allele with essential tremor (OR=1.37, 95% CI 1.02-1.86, p=0.03), confirming a previous European GWAS finding in an Asian population.

This case-control study examined whether LINGO1 gene variants (rs9652490, rs11856808, rs7177008) associated with essential tremor also confer risk for Parkinson's disease in an Austrian population of 349 PD patients and 345 controls. No significant associations were found between any LINGO1 SNP genotypes or alleles and PD (rs9652490 p=0.61), nor in the subgroup of tremor-dominant PD patients (n=34, p=0.76). The findings argue against a major role of LINGO1 variants in PD susceptibility despite the documented clinical overlap between the two disorders.

This case-control study investigated whether LINGO1 gene polymorphisms associated with essential tremor also confer risk for Parkinson's disease (PD). Three SNPs (rs9652490, rs11856808, rs7177008) were genotyped in 349 PD patients and 345 controls from Austria. No significant associations were found between any LINGO1 variants and PD risk overall (p=0.61 for rs9652490) or in tremor-dominant PD patients, arguing against a major role of LINGO1 variants in PD susceptibility.