rs7221167
This is a intron variant variant in the MAPT-AS1 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Parkinson disease
Nalls MA et al. “Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies.” The Lancet. Neurology 18(12):1091-1102 (2019)
Allele T
OR 0.14
p 1.0e-37
N 482,730
Meta-analysisLarge GWAS
European
Rodrigo LM et al. “Imputation and Reanalysis of ExomeChip Data Identifies Novel, Conditional and Joint Genetic Effects on Parkinson's Disease Risk.” Genes 12(5) (2021)
Allele T
OR 0.85
p 3.0e-8
N 10,533
Large GWAS
European
neuroticism measurement
Hill WD et al. “Genetic contributions to two special factors of neuroticism are associated with affluence, higher intelligence, better health, and longer life.” Molecular Psychiatry 25(11):3034-3052 (2020)
Allele T
OR 0.01
p 3.0e-8
N 270,059
Large GWAS
European
About MAPT-AS1
Involved in regulatory ncRNA-mediated gene silencing. Implicated in Parkinson's disease. [provided by Alliance of Genome Resources, Jul 2025]
View all MAPT-AS1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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