rs7241572

This variant is located in the KCNG2 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

major depressive disorder

Howard DM et al. “Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.” Nature Neuroscience 22(3):343-352 (2019)
Allele A
OR 1.02
p 3.0e-13
N 807,553
Meta-analysisLarge GWAS
European
Meng X et al. “Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference.” Nature Genetics 56(2):222-233 (2024)
Allele A
OR 0.03
p 1.0e-11
N 1,820,689
Large GWAS
multi-ancestry
Als TD et al. “Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses.” Nature Medicine 29(7):1832-1844 (2023)
Allele A
OR 0.03
p 1.0e-11
N 1,349,887
Large GWAS
European
Yao X et al. “Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders.” Translational Psychiatry 11(1):69 (2021)
Allele A
OR 0.03
p 3.0e-11
N 500,199
Large GWAS
European

About KCNG2

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit of the voltage-gated potassium channel. The delayed-rectifier type channels containing this subunit may contribute to cardiac action potential repolarization. [provided by RefSeq, Jul 2008]

View all KCNG2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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