rs72547529

This is a missense variant in the VKORC1 gene.

Key Literature Trait Associations

Warfarin Dose Requirement

This rare VKORC1 missense variant affects warfarin sensitivity independently of the common -1639G>A promoter variant. Carriers may require modified warfarin doses due to altered vitamin K epoxide reductase function. When detected alongside the common VKORC1 variants, it may help explain residual dose variability.

Brown KC et al. “Drug interactions with new and investigational antiretrovirals.” Clinical Pharmacokinetics 48(4):211-241 (2009)
Allele T
OR —
p —
Candidate gene study
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ClinVar annotation

Conflicting Classifications
2 submitters1 publication

Warfarin response; Vitamin K-dependent clotting factors, combined deficiency of, type 2

View on ClinVar →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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