rs7270785
This is a intron variant variant in the TGM2 gene.
▶Research that mentions this SNP (1)
▶The TGM2 gene is associated with schizophrenia in a British populationAssociationN=393Matilda Bradford et al.(2009)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Family-based association study of 131 British trios found the TGM2 gene is associated with schizophrenia. Four individual SNPs showed significant allelic associations: rs2076380 (P=0.019), rs7270785 (P=0.004), rs4811528 (P=0.013), and rs6023526 (P=0.013). The strongest association was observed for the rs7270785-rs4811528 two-SNP haplotype (P=0.001), and the 8-SNP haplotype A-T-A-A-T-G-A-G was excessively transmitted (P=0.0007).
About TGM2
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
View all TGM2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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