rs72725854

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GWAS Catalog Trait Associations (7)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

prostate cancer

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.82
p 7.0e-97
N 48,011
Major Consortium StudyLarge GWAS
African American or Afro-Caribbean
Janivara R et al. “Heterogeneous genetic architectures of prostate cancer susceptibility in sub-Saharan Africa.” Nature Genetics 56(10):2093-2103 (2024)
Allele A
OR 0.67
p 5.0e-37
N 7,472
Large GWAS
Sub-Saharan African

drug use measurement, prostate cancer

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.58
p 2.0e-25
N 48,011
Major Consortium StudyLarge GWAS
African American or Afro-Caribbean

prostate specific antigen amount

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.52
p 2.0e-105
N 100,875
Major Consortium StudyLarge GWAS
African American or Afro-Caribbean

prostate carcinoma

Wang A et al. “Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.” Nature Genetics 55(12):2065-2074 (2023)
Allele A
OR 2.38
p 2.0e-296
N 944,762
Large GWAS
multi-ancestry
Conti DV et al. “Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.” Nature Genetics 53(1):65-75 (2021)
Allele A
OR 2.09
p 4.0e-82
N 234,253
Meta-analysisLarge GWAS
multi-ancestry
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.88
p 9.0e-276
N 103,424
Major Consortium StudyLarge GWAS
African American or Afro-Caribbean
Du Z et al. “Genetic risk of prostate cancer in Ugandan men.” The Prostate 78(5):370-376 (2018)
Allele A
OR 3.37
p 2.0e-11
N 1,040
Large GWAS
Sub-Saharan African

radiation injury

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.55
p 6.0e-22
N 119,927
Major Consortium StudyLarge GWAS
African American or Afro-Caribbean

response to radiation

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.64
p 1.0e-31
N 121,504
Major Consortium StudyLarge GWAS
African American or Afro-Caribbean

Urinary incontinence

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.27
p 3.0e-17
N 115,522
Major Consortium StudyLarge GWAS
African American or Afro-Caribbean

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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