rs72833102

This variant is located in the MSI2 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

substance-related disorder

Lai D et al. “Genome-wide meta-analyses of cross substance use disorders in diverse populations.” Molecular Psychiatry 31(3):1619-1633 (2026)

Allele A

OR 7.19

p 7.0e-13

N 1,517,369

Large GWAS

multi-ancestry

cannabis dependence

Levey DF et al. “Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications.” Nature Genetics 55(12):2094-2103 (2023)

Allele A

OR 0.03

p 2.0e-8

N 200,762

Large GWAS

European

About MSI2

This gene encodes an RNA-binding protein that is a member of the Musashi protein family. The encoded protein is transcriptional regulator that targets genes involved in development and cell cycle regulation. Mutations in this gene are associated with poor prognosis in certain types of cancers. This gene has also been shown to be rearranged in certain cancer cells. [provided by RefSeq, Apr 2016]

View all MSI2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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