rs72931748

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

aortic measurement

Benjamins JW et al. “Genomic insights in ascending aortic size and distensibility.” Ebiomedicine 75:103783 (2022)

Allele A

OR 0.10

p 2.0e-16

N 31,908

Large GWAS

Francis CM et al. “Genome-wide associations of aortic distensibility suggest causality for aortic aneurysms and brain white matter hyperintensities.” Nature Communications 13(1):4505 (2022)

Allele A

OR 17.11

p 3.0e-16

N 32,590

Large GWAS

European

pulse pressure measurement

Keaton JM et al. “Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.” Nature Genetics 56(5):778-791 (2024)

Allele G

OR 0.25

p 4.0e-16

N 1,028,980

Large GWAS

multi-ancestry

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.02

p 3.0e-9

N 506,308

Large GWAS

multi-ancestry

systolic blood pressure

Allele G

OR 0.34

p 1.0e-15

N 1,028,980

Large GWAS

multi-ancestry

Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)

Allele G

OR 0.02

p 7.0e-13

N 1,212,859

Large GWAS

European

Giri A et al. “Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.” Nature Genetics 51(1):51-62 (2019)

Allele G

OR 0.30

p 7.0e-11

N 459,777

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

rs72931748

GWAS Catalog Trait Associations (3)

aortic measurement

pulse pressure measurement

systolic blood pressure

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