rs7295569

This variant is located in the DRAM1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

white matter volume measurement, cerebellar volume measurement

Primus SA et al. “Beyond volume: Unraveling the genetics of human brain geometry.” Science Advances 11(24):eadr1644 (2025)

Allele C

OR —

p 7.0e-10

N 19,862

Large GWAS

European

About DRAM1

This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq, Jul 2008]

View all DRAM1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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