DRAM1
DNA damage regulated autophagy modulator 1
Summary
This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq, Jul 2008]
Known Variants20 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs774126957 | 12:102,271,677 | A/T | — | uncertain significance |
| rs771878729 | 12:102,271,685 | C/T | — | uncertain significance |
| rs145219968 | 12:102,273,769 | G/A | — | — |
| rs190628513 | 12:102,275,076 | G/A | intron variant | — |
| rs543780679 | 12:102,281,266 | G/A | — | — |
| rs369517798 | 12:102,291,646 | C/T | — | uncertain significance |
| rs772368807 | 12:102,291,696 | T/G | — | uncertain significance |
| rs1282175016 | 12:102,295,120 | C/A | — | uncertain significance |
| rs1566126243 | 12:102,295,185 | G/A | — | uncertain significance |
| rs7295569 | 12:102,295,218 | T/G | — | — |
| rs1234792963 | 12:102,302,030 | A/G | — | uncertain significance |
| rs771666007 | 12:102,302,072 | T/G | — | uncertain significance |
| rs749800547 | 12:102,302,126 | G/A | — | uncertain significance |
| rs200817899 | 12:102,307,987 | C/A | — | uncertain significance |
| rs1053469717 | 12:102,307,991 | A/C | — | uncertain significance |
| rs7302651 | 12:102,311,265 | A/G | intron variant | — |
| rs565616480 | 12:102,313,902 | G/A | — | uncertain significance |
| rs61748066 | 12:102,315,025 | A/G | — | uncertain significance |
| rs17434787 | 12:102,315,791 | A/G | downstream gene variant | — |
| rs117146578 | 12:102,316,763 | T/C | downstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.