rs7305618

This is a downstream gene variant variant.

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GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

C-reactive protein measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele T
OR 0.09
p 3.0e-217
N 355,127
Major Consortium StudyLarge GWAS
multi-ancestry
Wu Y et al. “Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.” Inflammation 35(2):574-83 (2012)
Allele T
OR 0.27
p 1.0e-8
N 1,709
Large GWAS
Asian unspecified

serum gamma-glutamyl transferase measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele T
OR 0.07
p 8.0e-151
N 355,690
Major Consortium StudyLarge GWAS
multi-ancestry

alkaline phosphatase measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele T
OR 0.04
p 9.0e-39
N 355,891
Major Consortium StudyLarge GWAS
multi-ancestry

sex hormone-binding globulin measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele T
OR 0.03
p 6.0e-25
N 322,484
Major Consortium StudyLarge GWAS
multi-ancestry

IGF-1 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.02
p 2.0e-21
N 394,642
Large GWAS
European
Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele T
OR 0.02
p 4.0e-17
N 353,824
Major Consortium StudyLarge GWAS
multi-ancestry
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Research that mentions this SNP (2)

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Genetic variation of FTO: rs1421085 T&gt;C, rs8057044 G&gt;A, rs9939609 T&gt;A, and copy number (CNV) in Mexican Mayan school‐aged children with obesity/overweight and with normal weight
ReviewLizbeth González‐Herrera et al.(2019)· American Journal of Human Biology

A literature review of 70 studies examining single nucleotide polymorphisms (SNPs) associated with obesity in Mexican populations published 2011-2021. The authors identified SNPs with differential behavior in Mexican compared to Caucasian populations, including rs17782313 (MC4R), rs6548238 (TMEM18), rs6265 (BDNF), rs7498665 (SH2B1), and notably rs6232 (PCSK1) associated with early-onset obesity in Mexican youth. The review emphasizes ethnicity-dependent genetic effects on BMI heritability (40-70%) and highlights genes involved in cholesterol metabolism and adipokine signaling pathways.

Traits studied:AdiposityBlood pressureBody mass index (BMI)Cardiovascular risk factorsDyslipidemiaInsulin resistanceMetabolic syndromeObesityOverweightType 2 diabetes
PubMedDOIMetascience Observatory
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Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas
AssociationN=3,494Parra EJ et al.(2011)· Diabetologia

This genome-wide association study of type 2 diabetes in 967 Mexican cases and 343 normoglycaemic controls, meta-analyzed with a Mexican-American sample (1,804 cases, 780 controls), identified genome-wide significant associations (p<5×10⁻⁸) in HNF1A (rs7305618, OR=1.69) and CDKN2A/CDKN2B (rs1333051, OR=1.32), with suggestive associations in IGF2BP2 (rs1374910, OR=1.30), KCNQ1 (rs2237892, OR=1.26), and a novel locus near C14orf70 (rs730570, OR=1.21). Follow-up in the DIAGRAM+ European dataset confirmed HNF1A and KCNQ1 regions.

Traits studied:Type 2 diabetes
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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