rs73214144

This is a intron variant variant in the C12orf43 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

C-reactive protein measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)

Allele A

OR 0.04

p 8.0e-25

N 355,127

Major Consortium StudyLarge GWAS

multi-ancestry

serum gamma-glutamyl transferase measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)

Allele A

OR 0.02

p 2.0e-10

N 355,690

Major Consortium StudyLarge GWAS

multi-ancestry

About C12orf43

Predicted to be involved in Spemann organizer formation and negative regulation of Wnt signaling pathway. Predicted to be located in nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]

View all C12orf43 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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