rs7336610

This variant is located in the MIR17HG gene.

▶

ClinVar annotation

Benign
1 submitter

MIR17HG-related disorder

View on ClinVar →
▶

Research that mentions this SNP (2)

▶
Evaluation of SNPs inmiR-146a,miR196a2andmiR-499as low-penetrance alleles in German and Italian familial breast cancer cases
AssociationN=1,800Irene Catucci et al.(2010)· Human Mutation

This PhD thesis presents a comprehensive study of microRNA (miRNA) SNPs and their association with breast cancer risk in Australian Caucasian populations. The study identified three key findings: rs2910164 in MIR146A showed significant association (p=0.03 and p=0.00013 in two populations); rs353291 in MIR145 showed significant differences in allele frequencies (p=0.041 and p=0.023); and rs4284505/rs7336610 in the MIR17HG cluster showed significant association with protective effect (OR=0.75, 95% CI: 0.60-0.94, p=0.012).

Traits studied:Breast cancerBreast cancer risk
PubMedDOIMetascience Observatory
▶
Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high‐risk women
AssociationN=1,425Tair Kontorovich et al.(2010)· International Journal of Cancer

This PhD thesis presents three case-control association studies of microRNA SNPs in Australian Caucasian breast cancer populations. Study 1 found rs2910164 (MIR146A) significantly associated with sporadic breast cancer risk (OR: 1.774; 95% CI: 1.402-2.237; p=0.000001 combined). Study 2 identified rs353291 (MIR145) as associated with breast cancer (allelic p=0.041 GRC-BC, p=0.023 GU-CCQ BB; OR: 1.37 and 1.25 respectively). Study 3 found rs4284505 (MIR17HG) associated with reduced breast cancer risk (p=0.01 GRC-BC, p=0.03 GU-CCQ BB; OR: 0.70 and 0.79), with the rs4284505/rs7336610 haplotype AC conferring 25% reduced risk (OR: 0.75; 95% CI: 0.60-0.94; p=0.012).

Traits studied:Breast cancerSporadic breast cancer susceptibility
PubMedDOIMetascience Observatory

About MIR17HG

This gene is the host gene for the MIR17-92 cluster, a group of at least six microRNAs (miRNAs) that may be involved in cell survival, proliferation, differentiation, and angiogenesis. Amplification of this gene has been found in several lymphomas and solid tumors. Two non-protein coding transcript variants have been found for this host gene, but only the longest is a polycistronic transcript containing the MIR17-92 cluster. [provided by RefSeq, May 2012]

View all MIR17HG variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…