rs7349332

This is a intron variant variant in the WNT10A gene.

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

balding measurement

Yap CX et al. “Dissection of genetic variation and evidence for pleiotropy in male pattern baldness.” Nature Communications 9(1):5407 (2018)
Allele T
OR 0.06
p 2.0e-37
N 205,327
Large GWAS
European

androgenetic alopecia

Pirastu N et al. “GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.” Nature Communications 8(1):1584 (2017)
Allele C
OR 0.18
p 1.0e-19
N 43,590
Large GWAS
European

alopecia

Hagenaars SP et al. “Genetic prediction of male pattern baldness.” Plos Genetics 13(2):e1006594 (2017)
Allele T
OR —
β 0.071
p 2.0e-16
N 52,874
Large GWAS
European

hair morphology

Eriksson N et al. “Web-based, participant-driven studies yield novel genetic associations for common traits.” Plos Genetics 6(6):e1000993 (2010)
Allele T
OR 0.19
p 3.0e-14
N 9,126
Large GWAS
European

About WNT10A

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region. [provided by RefSeq, Jul 2008]

View all WNT10A variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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