rs73729085

This is a 3 prime utr variant variant in the CREB3L2 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

total cholesterol measurement

Kamiza AB et al. “Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry.” Nature Communications 14(1):5403 (2023)
Allele G
OR 0.07
p 9.0e-32
N 125,000
Large GWAS
African American or Afro-Caribbean, Sub-Saharan African, African unspecified
Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)
Allele G
OR 0.09
p 5.0e-26
N 99,432
Large GWAS
African American or Afro-Caribbean, African unspecified

About CREB3L2

This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

View all CREB3L2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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