rs7412746
This variant is located in the CTXND2 gene.
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
nevus count, cutaneous melanoma
Landi MT et al. “Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility.” Nature Genetics 52(5):494-504 (2020)
Allele C
OR —
p 7.0e-14
N 477,725
Large GWAS
European
melanoma
Macgregor S et al. “Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3.” Nature Genetics 43(11):1114-8 (2011)
Allele T
OR 1.15
p 9.0e-11
N 6,555
Large GWAS
European
Ransohoff KJ et al. “Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma.” Oncotarget 8(11):17586-17592 (2017)
Allele T
OR 1.15
p 9.0e-11
N 291,407
Large GWAS
European
forced expiratory volume
Schoeler T et al. “Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.” Nature Communications 16(1):4524 (2025)
Allele C
OR 0.01
p 1.0e-9
N 373,397
Large GWAS
European
forced expiratory volume, 25-hydroxyvitamin D3 measurement
Seo J et al. “Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function.” The American Journal of Clinical Nutrition 119(5):1227-1237 (2024)
Allele C
OR —
p 3.0e-9
N 115,312
Meta-analysisLarge GWAS
multi-ancestry
About CTXND2
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all CTXND2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…