rs7459962

This variant is located in the CHMP7 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

level of serum globulin type protein

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)

Allele G

OR 0.02

p 4.0e-9

N 325,292

Major Consortium StudyLarge GWAS

multi-ancestry

neuroimaging measurement

Bhatt RR et al. “The Genetic Architecture of the Human Corpus Callosum and its Subregions.” Nature Communications 16(1):9708 (2025)

Allele C

OR 0.07

p 6.0e-9

N 46,685

Large GWAS

European

About CHMP7

Involved in several processes, including midbody abscission; mitotic nuclear division; and vacuolar transport. Located in several cellular components, including bounding membrane of organelle; chromosome; and nucleus. Part of ESCRT III complex and nuclear pore. [provided by Alliance of Genome Resources, Jul 2025]

View all CHMP7 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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