rs74827081

This is a intron variant variant in the TACR3 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Hot flashes

Werwath KE et al. “Trans-ancestry GWAS of hot flashes reveals potent treatment target and overlap with psychiatric disorders.” Communications Medicine 6(1):51 (2026)

Allele G

OR 1.27

p 7.0e-41

N 149,560

Large GWAS

multi-ancestry

About TACR3

This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008]

View all TACR3 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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