rs74853338
This is a regulatory region variant variant in the SPATS2L gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
heart failure
Lee DSM et al. “Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum.” Nature Genetics 57(4):829-838 (2025)
Allele T
OR 0.03
p 5.0e-12
N 2,358,556
Large GWAS
multi-ancestry
Henry A et al. “Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes.” Nature Genetics 57(4):815-828 (2025)
Allele T
OR 0.03
p 5.0e-12
N 1,968,806
Meta-analysisLarge GWAS
multi-ancestry
substance-related disorder
Lai D et al. “Genome-wide meta-analyses of cross substance use disorders in diverse populations.” Molecular Psychiatry 31(3):1619-1633 (2026)
Allele T
OR 5.56
p 3.0e-8
N 1,699,295
Large GWAS
multi-ancestry
About SPATS2L
Enables RNA binding activity. Located in cytosol; nucleolus; and nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]
View all SPATS2L variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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