rs75128958

This is a intergenic variant variant in the LYPLAL1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

FEV/FVC ratio

Shrine N et al. “Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.” Nature Genetics 55(3):410-422 (2023)

Allele A

OR 10.60

p 3.0e-26

N 588,452

Large GWAS

multi-ancestry

Shrine N et al. “New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.” Nature Genetics 51(3):481-493 (2019)

Allele A

OR 0.04

p 2.0e-23

N 321,047

Large GWAS

European

About LYPLAL1

Enables palmitoyl-(protein) hydrolase activity. Involved in negative regulation of cGAS/STING signaling pathway. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

View all LYPLAL1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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