rs757318
This variant is located in the CRTC1 gene.
▶GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
body mass index
Sidorenko J et al. “Genetic architecture reconciles linkage and association studies of complex traits.” Nature Genetics 56(11):2352-2360 (2024)
Allele C
OR 0.02
p 2.0e-23
N 650,000
Large GWAS
European
Winkler TW et al. “The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.” Plos Genetics 11(10):e1005378 (2015)
Allele C
OR —
β 0.020
p 5.0e-13
N 309,889
Large GWAS
European
body weight
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.03
p 1.0e-17
N 609,198
Major Consortium StudyLarge GWAS
multi-ancestry
visceral adipose tissue quantity
Karlsson T et al. “Contribution of genetics to visceral adiposity and its relation to cardiovascular and metabolic disease.” Nature Medicine 25(9):1390-1395 (2019)
Allele A
OR 0.02
p 7.0e-14
N 325,153
Large GWAS
European
body fat percentage
Lu Y et al. “New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.” Nature Communications 7:10495 (2016)
Allele C
OR 0.04
p 5.0e-8
N 78,525
Large GWAS
multi-ancestry
physical activity measurement, body mass index
Graff M et al. “Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.” Plos Genetics 13(4):e1006528 (2017)
Allele C
OR 0.02
p 3.0e-8
N 161,368
Meta-analysisLarge GWAS
multi-ancestry
About CRTC1
Enables cAMP response element binding protein binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol; nuclear body; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all CRTC1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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