rs7590720

This genome-wide association study investigated the genetic basis of alcohol dependence (AD) in 7,842 Dutch participants using the AUDIT screening measure. Twin-based heritability was estimated at 60% (95% CI: 55-69%) and common SNPs explained 33% of this heritability. The GWAS identified four suggestive loci (4q34.1, 2p16.1, 6q25.3, 7p14.1) with the strongest association at rs55768019 (P=7.58×10⁻⁷, OR=0.80). Replication confirmed known AD variants: rs1229984 in ADH1B (P=1.58×10⁻⁴, OR=1.77) and rs7119734 in DSCAML1 (P=7.5×10⁻³, OR=1.16).

Genome-wide association study and replication study identifying susceptibility genes for alcohol dependence in 1460 German male patients with early-onset alcohol dependence and 2332 controls. Two SNPs met genome-wide significance: rs7590720 (p=9.72×10⁻⁹) and rs1344694 (p=1.69×10⁻⁸) on chromosome 2q35 near the PECR gene. Nine additional SNPs showed significant replication in genes including CDH13, ADH1C, CAST, and ERAP1.