rs75920871

This variant is located in the SIK3 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

wellbeing measurement

Kim S et al. “Shared genetic architectures of subjective well-being in East Asian and European ancestry populations.” Nature Human Behaviour 6(7):1014-1026 (2022)

Allele A

OR —

β 0.018

p 7.0e-9

N 674,095

Large GWAS

multi-ancestry

Turley P et al. “Multi-trait analysis of genome-wide association summary statistics using MTAG.” Nature Genetics 50(2):229-237 (2018)

Allele A

OR 0.02

p 1.0e-8

N 388,538

Large GWAS

European

About SIK3

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in positive regulation of TORC1 signaling; positive regulation of TORC2 signaling; and protein phosphorylation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

View all SIK3 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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