SIK3

SIK family kinase 3

Summary

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in positive regulation of TORC1 signaling; positive regulation of TORC2 signaling; and protein phosphorylation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants236 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs148841309	11:116,713,690	C/T	downstream gene variant	—
rs141469619	11:116,714,293	A/G	3 prime UTR variant	—
rs150767868	11:116,717,136	G/A	—	likely benign
rs775106145	11:116,717,167	A/G	—	uncertain significance
rs539085925	11:116,717,199	A/C	—	likely benign
rs1016240093	11:116,718,292	G/T	—	likely benign
rs2540354038	11:116,718,296	C/G	—	uncertain significance
rs628418	11:116,718,366	C/G	intron variant	—
rs61905155	11:116,718,929	G/T	—	—
rs773564219	11:116,719,840	G/A	—	uncertain significance
rs533326357	11:116,719,847	C/T	—	uncertain significance
rs780688517	11:116,719,912	C/T	—	uncertain significance
rs747877301	11:116,719,913	G/A	—	uncertain significance
rs146679016	11:116,719,941	C/T	—	benign
rs111894427	11:116,721,405	C/T	intron variant	—
rs10047462	11:116,722,041	G/T	intron variant	—
rs536258440	11:116,722,224	G/A	—	—
rs117221732	11:116,725,659	G/A	intron variant	—
rs181873174	11:116,726,640	G/A	downstream gene variant	—
rs10790165	11:116,727,270	T/G	—	—
rs625145	11:116,727,936	A/T	downstream gene variant	—
rs199982854	11:116,728,531	C/T	—	uncertain significance
rs767509939	11:116,728,562	T/C	—	likely benign
rs1457785172	11:116,728,569	A/T	—	uncertain significance
rs753476055	11:116,728,587	C/G	—	likely benign
rs12225230	11:116,728,630	G/C	missense variant	benign
rs369510716	11:116,728,646	C/T	—	uncertain significance
rs541502159	11:116,728,647	G/A	—	likely benign
rs775490759	11:116,728,666	C/T	—	uncertain significance
rs11216163	11:116,728,743	G/C	—	benign
rs768112808	11:116,728,783	T/A	—	uncertain significance
rs56161061	11:116,728,842	G/A	—	benign
rs56247967	11:116,728,889	C/T	—	likely benign
rs61738656	11:116,728,913	G/A	—	likely benign
rs556463758	11:116,728,915	T/G	—	uncertain significance
rs373958184	11:116,728,957	G/A	—	uncertain significance
rs149318611	11:116,728,984	A/G	—	uncertain significance
rs539858	11:116,729,013	T/C	—	benign
rs1565368928	11:116,729,030	G/A	—	uncertain significance
rs554996960	11:116,729,069	T/A	—	uncertain significance
rs140347311	11:116,729,082	G/A	—	likely benign
rs367650098	11:116,729,096	C/T	—	uncertain significance
rs55730930	11:116,729,161	T/C	—	likely benign
rs751117002	11:116,729,173	G/A	—	uncertain significance
rs541586	11:116,729,196	T/C	—	benign
rs770197979	11:116,729,203	G/A	—	uncertain significance
rs369719459	11:116,729,221	G/A	—	uncertain significance
rs184287857	11:116,729,270	G/A	—	uncertain significance
rs2540456943	11:116,729,336	C/T	—	uncertain significance
rs769019791	11:116,729,389	G/A	—	uncertain significance
rs2540463291	11:116,730,059	G/T	—	uncertain significance
rs187240549	11:116,730,062	C/T	—	uncertain significance
rs1943179913	11:116,730,104	A/G	—	uncertain significance
rs768087803	11:116,730,111	G/A	—	uncertain significance
rs190422062	11:116,730,231	C/T	—	likely benign
rs74794970	11:116,730,315	C/T	—	uncertain significance
rs1943308249	11:116,732,017	T/C	—	uncertain significance
rs368729211	11:116,732,020	G/T	—	uncertain significance
rs2075292	11:116,732,512	G/T	regulatory region variant	benign
rs766031308	11:116,732,927	T/A	—	uncertain significance
rs1373371959	11:116,732,935	G/T	—	uncertain significance
rs749367396	11:116,733,016	C/T	—	uncertain significance
rs773754069	11:116,734,454	G/A	—	uncertain significance
rs368046147	11:116,734,473	G/A	—	uncertain significance
rs138061274	11:116,734,496	G/A	—	uncertain significance
rs1352937328	11:116,734,518	A/G	—	uncertain significance
rs1943481687	11:116,734,519	G/C	—	uncertain significance
rs11216164	11:116,734,545	G/A	—	benign
rs187020791	11:116,737,570	C/G	intron variant	—
rs188287950	11:116,740,482	C/T	regulatory region variant	—
rs1229654347	11:116,741,075	C/T	—	uncertain significance
rs371384308	11:116,741,076	G/A	—	likely benign
rs533556	11:116,741,572	A/C	intron variant	—
rs79849088	11:116,742,626	C/T	intron variant	—
rs144767306	11:116,744,229	G/A	—	uncertain significance
rs751339743	11:116,744,234	C/T	—	uncertain significance
rs373483941	11:116,744,235	G/A	—	uncertain significance
rs138704851	11:116,744,290	C/T	—	likely benign
rs11216169	11:116,744,389	T/C	—	benign
rs376066531	11:116,744,637	G/A	—	likely benign
rs55767986	11:116,744,648	A/G	—	likely benign
rs184642028	11:116,744,761	A/G	—	uncertain significance
rs2540600317	11:116,745,971	G/T	—	uncertain significance
rs2540602185	11:116,746,126	C/G	—	uncertain significance
rs147293335	11:116,746,160	T/C	—	uncertain significance
rs770464219	11:116,746,166	G/A	—	uncertain significance
rs2540607933	11:116,746,608	C/T	—	uncertain significance
rs376144593	11:116,746,655	T/C	—	uncertain significance
rs746605300	11:116,746,697	T/C	—	uncertain significance
rs1425229878	11:116,746,704	C/T	—	uncertain significance
rs2540619128	11:116,747,674	A/C	—	likely pathogenic
rs12285074	11:116,762,028	G/A	upstream gene variant	—
rs781741381	11:116,767,012	G/A	—	likely benign
rs200501391	11:116,769,101	T/C	—	—
rs17120139	11:116,774,201	G/A	intron variant	—
rs78832854	11:116,774,475	T/A	intron variant	—
rs7111854	11:116,776,826	A/T	intron variant	—
rs75920871	11:116,780,095	A/G	—	—
rs553415662	11:116,782,574	T/A	—	—
rs11216185	11:116,782,974	T/G	intron variant	—

Showing 100 of 236 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.