rs76497186
This variant is located in the RPS6KC1 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
interleukin-6 measurement
Sherman BT et al. “Genome-wide association study of high-sensitivity C-reactive protein, D-dimer, and interleukin-6 levels in multiethnic HIV+ cohorts.” Aids (london, England) 35(2):193-204 (2021)
Allele C
OR 0.82
p 1.0e-8
N 7,052
Large GWAS
multi-ancestry
About RPS6KC1
Sphingosine kinase catalyzes the formation of sphingosine 1 phosphate, a lipid cellular messenger. The protein encoded by this gene can bind to sphingosine kinase and to phosphatidylinositol 3-phosphate, suggesting a role in sphingosine 1 phophate signaling. The encoded protein can also bind to peroxiredoxin-3 and may help transport it to mitochondria. [provided by RefSeq, Mar 2017]
View all RPS6KC1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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