rs7661964
This is a intron variant variant in the MTTP gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
non-alcoholic fatty liver disease
Chen Y et al. “Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease.” Nature Genetics 55(10):1640-1650 (2023)
Allele A
OR 7.00
p 3.0e-12
N 691,479
Meta-analysisLarge GWAS
South Asian, European, African American or Afro-Caribbean, East Asian, Hispanic or Latin American
About MTTP
MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]
View all MTTP variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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