rs76891117

This is a upstream gene variant variant in the DCAF4 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

serum gamma-glutamyl transferase measurement

Ghouse J et al. “Integrative common and rare variant analyses provide insights into the genetic architecture of liver cirrhosis.” Nature Genetics 56(5):827-837 (2024)

Allele G

OR 0.01

p 6.0e-13

N 875,069

Large GWAS

European

pulse pressure measurement

Keaton JM et al. “Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.” Nature Genetics 56(5):778-791 (2024)

Allele G

OR 0.19

p 3.0e-11

N 1,028,980

Large GWAS

multi-ancestry

systolic blood pressure

Allele G

OR 0.22

p 4.0e-8

N 1,028,980

Large GWAS

multi-ancestry

About DCAF4

This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]

View all DCAF4 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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