rs76928645
▶GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
thalamus volume
Elvsåshagen T et al. “The genetic architecture of the human thalamus and its overlap with ten common brain disorders.” Nature Communications 12(1):2909 (2021)
Allele T
OR 67.40
p 7.0e-19
N 30,114
Large GWAS
European
neuroimaging measurement
Bhatt RR et al. “The Genetic Architecture of the Human Corpus Callosum and its Subregions.” Nature Communications 16(1):9708 (2025)
Allele T
OR 6.55
p 4.0e-17
N 46,685
Large GWAS
European
brain volume
Smith SM et al. “An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank.” Nature Neuroscience 24(5):737-745 (2021)
Allele T
OR 0.11
p 2.0e-11
N 21,282
Major Consortium StudyLarge GWAS
European
Alzheimer disease
Bellenguez C et al. “New insights into the genetic etiology of Alzheimer's disease and related dementias.” Nature Genetics 54(4):412-436 (2022)
Allele T
OR 0.93
p 2.0e-10
N 487,511
Large GWAS
European
Dalmasso MC et al. “The first genome-wide association study in the Argentinian and Chilean populations identifies shared genetics with Europeans in Alzheimer's disease.” Alzheimer's & Dementia : the Journal of the Alzheimer's Association 20(2):1298-1308 (2024)
Allele T
OR 0.93
p 2.0e-8
N 488,904
Large GWAS
multi-ancestry
cortical thickness
Zhukovsky P et al. “Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression.” Nature Communications 15(1):5207 (2024)
Allele T
OR —
p 2.0e-9
N 34,544
Large GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…