rs77359862
This is a protein-altering variant in the SHARPIN gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
hippocampal volume
Park JY et al. “A missense variant in SHARPIN mediates Alzheimer's disease-specific brain damages.” Translational Psychiatry 11(1):590 (2021)
Allele A
OR 0.60
p 5.0e-11
N 2,643
Large GWAS
East Asian
cortical thickness
Park JY et al. “A missense variant in SHARPIN mediates Alzheimer's disease-specific brain damages.” Translational Psychiatry 11(1):590 (2021)
Allele A
OR 0.58
p 2.0e-8
N 2,643
Large GWAS
East Asian
About SHARPIN
Enables polyubiquitin modification-dependent protein binding activity. Involved in defense response to bacterium; protein linear polyubiquitination; and regulation of signal transduction. Located in cytosol. Part of LUBAC complex. [provided by Alliance of Genome Resources, Jul 2025]
View all SHARPIN variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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