rs776434
This is a intron variant variant in the FRS2 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
urinary albumin to creatinine ratio
Teumer A et al. “Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.” Nature Communications 10(1):4130 (2019)
Allele A
OR 0.02
p 4.0e-14
N 564,257
Large GWAS
multi-ancestry
Moderate albuminuria
Teumer A et al. “Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.” Nature Communications 10(1):4130 (2019)
Allele A
OR 1.05
p 3.0e-11
N 348,954
Large GWAS
European, South Asian, East Asian, African American or Afro-Caribbean, Hispanic or Latin American
About FRS2
Enables fibroblast growth factor receptor binding activity and neurotrophin TRKA receptor binding activity. Involved in negative regulation of cardiac muscle cell differentiation. Acts upstream of or within fibroblast growth factor receptor signaling pathway. Located in adherens junction. Biomarker of renal cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025]
View all FRS2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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