FRS2
fibroblast growth factor receptor substrate 2
Summary
Enables fibroblast growth factor receptor binding activity and neurotrophin TRKA receptor binding activity. Involved in negative regulation of cardiac muscle cell differentiation. Acts upstream of or within fibroblast growth factor receptor signaling pathway. Located in adherens junction. Biomarker of renal cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants31 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2870898 | 12:69,866,114 | C/G | — | — |
| rs1573630 | 12:69,870,219 | G/A | — | — |
| rs776434 | 12:69,934,116 | A/C | intron variant | — |
| rs746564330 | 12:69,964,192 | C/T | — | uncertain significance |
| rs768142080 | 12:69,964,193 | G/A | — | uncertain significance |
| rs200152963 | 12:69,964,199 | G/A | — | uncertain significance |
| rs759767008 | 12:69,965,088 | G/C | — | uncertain significance |
| rs770664718 | 12:69,965,203 | G/A | — | uncertain significance |
| rs371505814 | 12:69,967,833 | C/T | — | uncertain significance |
| rs2498956571 | 12:69,967,864 | G/A | — | uncertain significance |
| rs772522445 | 12:69,967,875 | G/A | — | uncertain significance |
| rs747379608 | 12:69,967,884 | A/T | — | uncertain significance |
| rs1881009924 | 12:69,968,018 | A/T | — | uncertain significance |
| rs1433286334 | 12:69,968,092 | G/A | — | uncertain significance |
| rs1287181147 | 12:69,968,121 | G/A | — | uncertain significance |
| rs758502066 | 12:69,968,179 | G/A | — | uncertain significance |
| rs2498959120 | 12:69,968,200 | C/T | — | uncertain significance |
| rs755320559 | 12:69,968,214 | A/G | — | uncertain significance |
| rs1881033663 | 12:69,968,238 | A/G | — | uncertain significance |
| rs187299511 | 12:69,968,292 | C/T | — | uncertain significance |
| rs756070543 | 12:69,968,335 | C/T | — | uncertain significance |
| rs1355686269 | 12:69,968,370 | C/G | — | uncertain significance |
| rs375527184 | 12:69,968,371 | C/A | — | uncertain significance |
| rs773329122 | 12:69,968,442 | C/T | — | uncertain significance |
| rs375588784 | 12:69,968,484 | C/T | — | uncertain significance |
| rs945337284 | 12:69,968,485 | G/A | — | uncertain significance |
| rs777663604 | 12:69,968,517 | A/G | — | uncertain significance |
| rs772087017 | 12:69,968,574 | C/T | — | uncertain significance |
| rs756943704 | 12:69,968,625 | G/A | — | uncertain significance |
| rs1026016008 | 12:69,968,652 | A/G | — | uncertain significance |
| rs2588440 | 12:69,971,474 | G/T | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.