rs7764856

▶

GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

interleukin-5 receptor subunit alpha measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.04
p 2.0e-16
N 47,745
Large GWAS
European

age-related hearing impairment

Trpchevska N et al. “Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss.” American Journal of Human Genetics 109(6):1077-1091 (2022)
Allele A
OR 0.01
p 1.0e-10
N 723,266
Meta-analysisLarge GWAS
European
▶

Research that mentions this SNP (1)

▶
Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non‐DRB1 loci
AssociationN=1,832Charlotte Vignal et al.(2009)· Arthritis &amp; Rheumatism

This case-control study of 855 rheumatoid arthritis patients and 977 controls identified SNP associations in the MHC region using logistic regression across 2,360 markers. After adjusting for HLA-DRB1, 18 markers in 14 genes showed strong associations (P < 10^-4). The final model retained three independent markers: rs4678 in VARS2L (nonsynonymous R/Q at position 1049), rs2442728 upstream of HLA-B, and rs17499655 in HLA-DQA2 5'-UTR, confirming polygenic MHC contribution to RA beyond the shared epitope.

Traits studied:Anti-cyclic citrullinated peptide (anti-CCP) antibodiesRheumatoid ArthritisRheumatoid Factor (RF) seropositivity
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…