rs77677460
This is a intron variant variant in the HSD17B12 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
chronotype measurement
Li X et al. “Automated feature extraction from population wearable device data identified novel loci associated with sleep and circadian rhythms.” Plos Genetics 16(10):e1009089 (2020)
Allele G
OR 0.47
p 1.0e-8
N 90,515
Large GWAS
About HSD17B12
This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation. [provided by RefSeq, Oct 2011]
View all HSD17B12 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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