rs7770794

This is a splice region variant variant in the IPCEF1 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

hypothyroidism

White SL et al. “Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.” Nature Genetics 58(2):307-316 (2026)

Allele A

OR 0.02

p 4.0e-11

N 2,444,128

Large GWAS

multi-ancestry

asthma

Valette K et al. “Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank.” Communications Biology 4(1):700 (2021)

Allele A

OR 0.04

p 9.0e-9

N 408,422

Major Consortium StudyLarge GWAS

European

About IPCEF1

Predicted to enable peroxidase activity. Predicted to be involved in response to oxidative stress. Predicted to be located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all IPCEF1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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