rs7778413

This is a regulatory region variant variant in the SND1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

insomnia

Watanabe K et al. “Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways.” Nature Genetics 54(8):1125-1132 (2022)
Allele T
OR 0.01
p 1.0e-10
N 2,365,010
Meta-analysisLarge GWAS
European
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Research that mentions this SNP (1)

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Single nucleotide polymorphisms in transcription factor genes associated with susceptibility to oral cancer
AssociationN=1,000Hetal Damani Shah et al.(2020)· Journal of Cellular Biochemistry

Case-control study of 500 oral cancer patients and 500 healthy tobacco users from India identifying 5 SNPs in transcription factor genes associated with increased oral cancer risk: rs2051526 (ETV6, OR=1.98), rs6021247 (NFATC2, OR=2.77), rs3757769 (SND1, OR=2.09), rs7085532 (TCF7L2, OR=12.16), and rs7778413 (SND1, OR=34.60). Coinheritance of rs6021247 GG and rs7778413 CC genotypes showed dramatic increased risk (OR=49.94).

Traits studied:Oral cancer susceptibilitySquamous cell carcinoma of the oral cavity
PubMedDOIMetascience Observatory

About SND1

This gene encodes a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transformation. Other transcription factors that interact with this protein are signal transducers and activators of transcription, STATs. This protein is also thought to be essential for normal cell growth. A similar protein in mammals and other organisms is a component of the RNA-induced silencing complex (RISC). [provided by RefSeq, Jul 2016]

View all SND1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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