rs77797441
This is a intron variant variant in the ANAPC1 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
corneal resistance factor
Khawaja AP et al. “Genetic Variants Associated With Corneal Biomechanical Properties and Potentially Conferring Susceptibility to Keratoconus in a Genome-Wide Association Study.” Jama Ophthalmology 137(9):1005-1012 (2019)
Allele T
OR 0.21
p 8.0e-12
N 6,645
Large GWAS
European
About ANAPC1
This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011]
View all ANAPC1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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