ANAPC1

anaphase promoting complex subunit 1

Summary

This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011]

Known Variants124 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs1044864	2:112,526,866	G/A	—	benign
rs746095622	2:112,529,969	C/T	—	uncertain significance
rs753847050	2:112,530,044	C/T	—	uncertain significance
rs757342710	2:112,530,050	C/T	—	uncertain significance
rs76210128	2:112,532,987	C/T	upstream gene variant	—
rs55913672	2:112,533,680	A/T	upstream gene variant	—
rs939797	2:112,536,264	G/T	—	benign
rs745357859	2:112,536,279	C/T	—	uncertain significance
rs1376691721	2:112,536,313	A/G	—	uncertain significance
rs80272729	2:112,538,247	G/A	—	—
rs77797441	2:112,539,384	C/T	intron variant	—
rs187208725	2:112,539,947	T/C	—	uncertain significance
rs1213848741	2:112,540,033	C/G	—	uncertain significance
rs199539393	2:112,540,065	C/G	—	uncertain significance
rs2466898784	2:112,541,925	A/G	—	uncertain significance
rs2466898859	2:112,541,935	G/C	—	uncertain significance
rs767964702	2:112,541,962	C/T	—	uncertain significance
rs776199700	2:112,541,968	A/G	—	uncertain significance
rs751341287	2:112,542,971	G/A	—	uncertain significance
rs756193157	2:112,543,025	T/C	—	uncertain significance
rs374211993	2:112,543,052	T/C	—	uncertain significance
rs1246518077	2:112,545,827	G/C	—	uncertain significance
rs765246504	2:112,545,875	A/G	—	uncertain significance
rs142179264	2:112,545,878	T/G	—	uncertain significance
rs779786301	2:112,550,048	C/T	—	uncertain significance
rs752971771	2:112,550,101	C/A	—	uncertain significance
rs761148732	2:112,550,102	T/C	—	uncertain significance
rs576922362	2:112,550,141	T/G	—	likely benign
rs2030500	2:112,550,325	C/T	—	—
rs1267333057	2:112,552,394	C/T	—	pathogenic
rs56780932	2:112,552,427	C/T	—	benign
rs1376040686	2:112,558,448	T/C	—	uncertain significance
rs2466967048	2:112,560,010	G/A	—	uncertain significance
rs1251360703	2:112,560,048	A/G	—	uncertain significance
rs1305948219	2:112,561,382	T/C	—	uncertain significance
rs1678546726	2:112,561,392	A/T	—	uncertain significance
rs752887546	2:112,563,414	C/T	—	uncertain significance
rs201128688	2:112,566,517	C/T	splice region variant	—
rs2466990104	2:112,566,529	T/C	—	uncertain significance
rs1318689701	2:112,566,534	C/G	—	uncertain significance
rs1239075020	2:112,566,539	G/C	—	uncertain significance
rs1202114204	2:112,566,685	A/G	—	uncertain significance
rs751433263	2:112,566,686	T/C	—	uncertain significance
rs2466990968	2:112,566,730	A/G	—	uncertain significance
rs199837741	2:112,578,833	G/C	—	uncertain significance
rs1679517063	2:112,578,841	C/T	—	uncertain significance
rs149905694	2:112,578,860	G/A	—	likely benign
rs747530702	2:112,578,883	C/G	—	uncertain significance
rs548028803	2:112,578,922	C/T	—	conflicting classifications of pathogenicity
rs905983604	2:112,578,945	A/G	—	uncertain significance
rs2467034836	2:112,579,009	A/G	—	uncertain significance
rs2467034930	2:112,579,030	C/T	—	uncertain significance
rs1267075110	2:112,580,025	C/T	—	uncertain significance
rs2467039443	2:112,580,145	A/G	—	uncertain significance
rs1573394192	2:112,580,151	G/C	—	uncertain significance
rs992863533	2:112,580,171	G/A	—	uncertain significance
rs528718391	2:112,582,591	A/T	—	uncertain significance
rs182214701	2:112,582,620	G/A	—	benign
rs141439178	2:112,582,713	T/C	—	likely benign
rs999743155	2:112,582,942	G/A	—	pathogenic
rs2467055615	2:112,583,368	G/C	—	likely benign
rs767121801	2:112,583,390	C/T	—	uncertain significance
rs1334845011	2:112,583,401	C/T	—	uncertain significance
rs747219169	2:112,588,904	A/G	—	uncertain significance
rs145838393	2:112,588,922	C/T	—	likely benign
rs147457004	2:112,588,975	G/A	—	likely benign
rs761620293	2:112,588,987	G/T	—	uncertain significance
rs750341130	2:112,589,002	C/T	—	uncertain significance
rs148461319	2:112,590,825	A/G	—	likely benign
rs139503565	2:112,590,838	G/A	—	uncertain significance
rs769523865	2:112,590,839	T/C	—	uncertain significance
rs76010034	2:112,592,195	G/A	—	benign
rs80165604	2:112,592,249	C/T	—	benign
rs368590852	2:112,592,278	A/T	—	uncertain significance
rs1320117347	2:112,592,304	A/C	—	uncertain significance
rs753333515	2:112,592,385	G/C	—	uncertain significance
rs768514607	2:112,592,416	G/C	—	uncertain significance
rs1680379496	2:112,592,419	G/A	—	uncertain significance
rs748248059	2:112,592,441	T/G	—	uncertain significance
rs1240940944	2:112,596,052	G/A	—	uncertain significance
rs776057720	2:112,601,009	G/A	—	uncertain significance
rs1267941411	2:112,601,020	T/G	—	uncertain significance
rs182422795	2:112,601,027	T/C	—	uncertain significance
rs765989849	2:112,601,030	T/C	—	uncertain significance
rs201732791	2:112,601,102	T/C	—	uncertain significance
rs746065457	2:112,601,127	T/G	—	likely benign
rs2467138711	2:112,601,129	C/G	—	uncertain significance
rs144034109	2:112,601,170	G/A	—	uncertain significance
rs143278866	2:112,604,729	G/A	—	uncertain significance
rs4848197	2:112,605,302	C/T	—	benign
rs1351214585	2:112,605,306	G/A	—	uncertain significance
rs767571503	2:112,605,400	T/C	—	uncertain significance
rs4848800	2:112,605,465	T/C	—	benign
rs551412961	2:112,608,424	G/A	—	uncertain significance
rs2467173185	2:112,608,456	G/T	—	uncertain significance
rs1394048500	2:112,614,204	G/A	—	uncertain significance
rs146218010	2:112,614,254	T/A	—	conflicting classifications of pathogenicity
rs1681753836	2:112,614,418	A/T	—	uncertain significance
rs72936240	2:112,614,429	G/A	—	benign
rs2467203235	2:112,615,921	C/A	—	uncertain significance

Showing 100 of 124 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.