rs7846438
This is a intron variant variant in the C8orf34 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
cartilage thickness measurement
Faber BG et al. “The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: findings from a genome-wide association study meta-analysis of minimum joint space width and Mendelian randomisation cluster analyses.” Ebiomedicine 95:104759 (2023)
Allele A
OR 0.06
p 1.0e-17
N 50,745
Meta-analysisLarge GWAS
European
About C8orf34
This gene encodes a protein that is related to the cyclic AMP dependent protein kinase regulators. Naturally occurring mutations in this gene are associated with an increased risk for severe toxicities, such as diarrhea and neutropenia, in patients undergoing chemotherapeutic treatment. [provided by RefSeq, Mar 2017]
View all C8orf34 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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